Epitalon
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What Is Epitalon? A primary peptide studied for longevity
Epitalon (also written Epithalon or Epithalone, CAS 307297-39-8) is a synthetic tetrapeptide developed by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology. The compound was designed based on Epithalamin, a natural peptide fraction extracted from bovine pineal gland tissue.
Researchers synthesized the four-amino acid sequence Ala-Glu-Asp-Gly to create a stable, reproducible research compound that could be studied without relying on biological extracts
Key Research Applications
Telomere elongation: Epitalon activates telomerase reverse transcriptase (hTERT), enabling DNA telomere elongation in human somatic cells and counteracting the Hayflick limit of replicative senescence.
Pineal gland regulation: The tetrapeptide modulates melatonin synthesis in the pineal gland, potentially restoring age-related declines in melatonin production that contribute to disrupted circadian rhythms and reduced antioxidant defense.
Antioxidant enzyme support: Research demonstrates the compound increases superoxide dismutase (SOD), catalase, and glutathione peroxidase activity, reducing oxidative DNA damage and lipid peroxidation markers in aged animal models.
Neuroendocrine normalization: Studies in aged animal models document normalized anterior pituitary function and restored luteinizing hormone and follicle-stimulating hormone pulsatility following administration.
Cellular senescence research: As a telomerase activator, this compound is a primary research tool in studies of cellular senescence, replicative lifespan, and the biology of the Hayflick limit.
RESEARCH USE ONLY. Not for human consumption. Not evaluated by the FDA. Not a drug, food, or cosmetic. Purchaser confirms status as a qualified researcher and assumes full responsibility for lawful, compliant use.
